A Sensitive and Efficient Method to Analyze THC and THCCOOH in Oral Fluid Using LC-MS/MS in Forensic Toxicology Laboratories

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Detection of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH) quantification requires highly sensitive analytical methods as it is present in low pg/mL concentrations in oral fluid (OF).

This application note demonstrates a sensitive and efficient LC-MS/MS method for simultaneous quantification of THCCOOH and THC, extracted from oral fluid, in forensic toxicology laboratories. Both analytes were extracted using a simple and fast SPE method without pre-conditioning, evaporation, or reconstitution. THCCOOH was detected
with high sensitivity (LOQ 10 pg/mL), and no
derivatization procedure was required.

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