The United States Pharmacopeia (USP) 2232 designates permitted daily exposure (PDE) levels for
four elements for which toxicity is a concern in dietary supplements. PDE values need to be
converted to concentrations when evaluating metallic impurities in formulations or their
structural components. Compliance with these regulations is also obligatory for supplements
imported to the U.S. from other nations.
Here, a quantitative analysis performed on arsenic,
cadmium, mercury, and lead in supplements using the Shimadzu ICPMS-2030 ICP mass spectrometer
is presented.
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