Big Pain Assays Aren't a Big Pain with the Raptor Biphenyl LC Column

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The use of pain management drugs is steadily increasing. Therapeutic drug monitoring can be challenging due to the low cutoff levels, potential matrix interferences, and isobaric drug compounds. To address these challenges, many drug testing facilities are turning to liquid chromatography coupled with mass spectrometry (LC-MS/MS) for its increased speed, sensitivity, and specificity.

This application note demonstrates how Restek’s Raptor™ Biphenyl column is ideal for developing successful LC-MS/MS pain medication screening methodologies. With its exceptionally high retention and unique selectivity, 231 multiclass drug compounds and metabolites — including over 40 isobars — can be analysed in just 10 minutes.

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