Determination of Iodinated Contrast Media by Direct Injection LC-MS/MS

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Determination of iodinated contrast media in aqueous samples was performed by fast chromatography on an Agilent 1290 Infinity II LC that included an Agilent 1290 Infinity II Multisampler equipped with a 100 μL analytical head and loop cartridge. Detection was done with an Agilent 6495 Triple Quadrupole LC/MS. With this configuration, it was possible to detect the contrast agents at the low ng/L parts per trillion (ppt) level in water without any pretreatment except filtration. The method was developed for seven target contrast agents, and the performance and figures of merit were investigated on standard solutions as well as on various water samples.

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