Determination of Veterinary Drug Residues in Milk Using Polymeric SPE and UHPLC-MS/MS Analysis

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This application note outlines a multi-class, multi-residue method for the determination of 49 representative veterinary drugs in milk using a simple, solid-phase extraction (SPE) procedure and analysis by UHPLC-MS/MS. To achieve fast and
simultaneous extraction of the various drug residues, a generic liquid extraction procedure using EDTA/acetic acid buffer is conducted prior to extraction on a polymeric SPE cartridge. UHPLC separation is carried out with a Selectra^® DA column, which exhibits alternative selectivity to a C18 phase and is capable of enhanced retention for the more polar drugs.

The drugs investigated belonged to several different classes, including β-agonists, macrolides, amphenicols, sulfonamides, tetracyclines and quinolones.

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