Comprehensive Screen of Acidic/Neutral/Basic Drugs from Blood and Urine Featuring a Direct Elution to Analysis Technique via LC-MS/MS



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Comprehensive screening is often referred to as general unknown or systematic toxicological analysis. It is in most cases the first line of defense when determining the presence of drugs of abuse.

This featured application note exploits the highly retentive, universal nature of UCT’s polymeric Styre Screen® HLD sorbent for the analysis of acidic, neutral, and basic compounds in blood and urine. The
generalized protocol not only minimizes unnecessary sample preparation steps, but also it allows for the LC-MS friendly elution solvent to go directly into an autosampler vial for further analysis.

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