Quantitative drug metabolite profiling is an important application in the pharmaceutical industry. Researchers involved in drug development require an analytical technique with a response that is independent of compound structure. This compound-independent response enables accurate quantification of the drug and its metabolites, without requiring compound-specific calibration. Currently, radiolabeling techniques followed by HPLC separation and radiodetection are used for this application, but a simpler, quicker, and safer alternative approach is desirable.
Chlorine-based drugs, metabolites and related compounds were separated using reversed phase (RP) HPLC. Quantification was by compound-independent calibration, based on measuring the chlorine (Cl) heteroatom using triple quadrupole ICP-MS (ICP-QQQ).
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