Rapid Characterization of Biologics using a CESI 8000 – AB SCIEX TripleTOF® 5600+ System


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Monoclonal antibodies (mAbs) make up an important class of biotherapeutics undergoing significant growth in the pharmaceutical industry today. Currently, more than 30 mAbs have been approved for use in treatment of a number of indications ranging from various forms of cancer to autoimmune and infectious diseases.

This technical note describes the comprehensive characterization of a representative monoclonal antibody Trastuzumab (Herceptin), illustrating the benefits of CESI coupled with high resolution mass spectrometry.

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