Routine Workflow for Comparability Assessment of Protein Biopharmaceuticals using High-resolution LC-MS


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Intact mass analysis using LC-MS provides a rapid assessment for the mass of a biomolecule as well as high level heterogeneity information. The ability to accomplish this assay rapidly often makes it a key assessment prior to more extensive investigation.  Here we demonstrate a reproducible and robust method for analysing intact biotherapeutic proteins on the X500B QTOF System with automated batch processing using BioPharmaView™ Software.

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