This application note demonstrates the use of the Agilent 1200 Infinity Series Online-SPE solution coupled to an Agilent Ultivo triple quadrupole LC/MS for the detection of trace organic contaminants in water at low levels (ng/L).
The method takes advantage of large volume injection of water samples to avoid tedious offline sample preparation and enrichment. The Ultivo houses many technological innovations that allow the instrument footprint to be reduced, yet maintain sensitivity. In this study, 51 compounds were detected under simultaneous positive and negative electrospray ionization modes using fast polarity switching. System performance was demonstrated by linearity, limits of detection (LOD), and relative standard deviation (RSD).
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