Top-down proteomics allows more powerful, reliable data to be obtained, as it directly analyses intact proteins before fragmentation and allows analysis of unique proteoforms using mass spectrometry. Mass spectrometry-based top-down proteomics has unique advantages for unravelling the molecular complexity, quantifying proteoforms, deep sequencing of intact proteins, mapping modification sites with full sequence coverage, discovering unexpected modifications, identifying and quantifying positional isomers and determining the order of multiple modifications.
Innovative integrated top-down proteomics can enable researchers to examine biomarkers in healthy and diseased models, to characterize any protein modifications present.
To download the story of how Professor Ge from the University of Wisconsin, in collaboration with Bruker, is using cutting-edge mass spectrometry platforms to drive developments in top-down proteomics, complete the form right.
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