Online 2D-LC Characterization of Monoclonal Antibodies

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The characterization of biopharmaceuticals can be highly complex and extensive to evaluate all important quality attributes. Online 2D-LC analysis enables a combination of different analysis methods to monitor different parameters in one run. This Application Note shows a combination of protein A titer analysis in the first dimension followed by ion exchange chromatography for charge variant analysis. The setup using high-resolution sampling provides for highly precise analysis regarding retention time and area and enables time-saving and easy monitoring for process or quality control of monoclonal antibodies.

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