Since achieving sufficient retention and favorable separation in normal batch analysis of highly polar pesticides has proved difficult due to their chemical characteristics, a number of individual analysis methods are employed for LC-MS/MS analysis. All of these methods have restrictions on the chemical compounds that can be analysed together and this remains a problem.
On the contrary, supercritical fluid chromatography (SFC) has the advantage of being able to separate a wide array of chemical compounds at once due to the characteristics of the mobile phase that is used. This article introduces an example of batch analysis of highly polar pesticides using SFC.
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