Sensitive, Robust Quantitative Analysis of a Mixture of Drug Candidates in Plasma using a TSQ Altis Triple Quadrupole Mass Spectrometer

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Small molecules represent a significant proportion of drug discovery and development in the search for new chemical entities, in addition to the extensive work involved in the regulatory filings of generics. Targeted quantitation assays are a critical part of an optimal workflow, which is required to successfully develop a small molecule drug. These targeted quantitation analyses must be done in biological matrices, which can often create analytical challenges. This study reports on the development of a sensitive, robust, reliable, and reproducible LC-MS/MS assay for multiple drug standards in rat plasma.

The application note demonstrates how the TSQ Altis triple quadrupole mass spectrometer provides the sensitivity and reproducibility required in the analysis of pharmaceutical compounds.

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