Tackling the Extended List of Fragrance Allergens by Flow-modulated GC×GC–TOF MS/FID

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This preliminary study investigates the use of flow-modulated GC×GC to analyse an 84-component allergen calibration standard, with simultaneous detection by TOF MS for confident identification and
FID for robust quantitation. A high degree of linearity and repeatability is demonstrated, showing that flow-modulated GC×GC is a promising approach for high-throughput quality control of fragranced products.
The validity of the GC×GC–TOF MS/FID method is then demonstrated with the examples of essential oils and a fragrance mix.

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